تحضير وتشخيص ودراسة الفعالية ضد سرطان الثدي لمشتقات جديدة لعقار الترايمثوبريم
Preparation, Characterization and Study of the Anti-Breast Cancer Activity of New Derivatives of Trimethoprim Drug
- الباحث
- زينب محمد فرحان
- المشرف
- أ.د. نغم محمود الجمالي
- الجامعة
- جامعة الكوفة
- الكلية / القسم
- التربية للبنات / الكيمياء
- الشهادة
- ماجستير
- السنة
- 2022
- لغة الرسالة
- عربي
- الكلمات المفتاحية
- الترايمثوبريم;الفورمازان;السلفازان;سرطان الثدي
Abstract
is study included the preparation of new compounds of Imine Compounds derived from a drug) Trimethoprim( as a basic compound in the preparation, by linking with the imine group (-HC=N-) in the compounds after losing a proton atom and replacing it with the azo group in diazonium salts by reaction in special conditions, as a result, a new class of organic compounds called formazan, cyclic innovated formazan and innovative sulfaZane. They have been studied their chemical structures proven and diagnosed by the three spectroscopic methods: infrared (FT-IR) for all the prepared compounds, and 1H.NMR for all the prepared compounds, as well as the carbon nuclear resonance (13C.NMR) spectrum, Some physical properties such as melting points (M.P), colors and others were measured and recorded, and all chemical reactions were followed by thin layer chromatography (TLC). As for the application side of the study, it included studying the carcinogenic activity of three derivatives, namely, the usual linear formazan, the innovative macro cyclic formazan, and the innovative sulfazan on two cell lines (MCF-10 A and MCF-7). Together to find out which one is the most efficient in the vital aspect to determine the extent of benefit from these compounds .
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