تحضير وتشخيص مركبات حلقية غير متجانسة عن طريق تفاعل الغلق الحلقي للإيمينات وتقييم فعاليتها البايولوجية

الباحث

احمد مهدي صالح

المشرف

مهند يقظان صالح

الجامعة

جامعة الموصل

الكلية / القسم

كلية التربية للعلوم الصرفة / قسم الكيمياء

الشهادة

ماجستير

السنة

2022

لغة الرسالة

عربي

الكلمات المفتاحية

المركبات الحلقية غير المتجانسة ; الإيمينات ; الغلق الحلقي ; الفعالية البايولوجية

A In this research, the synthesis and identification of a number of heterocyclic compounds, starting with the four membered ring as derivatives of azitidine-2-on and five- membered ring such as the thiazolidine-4-one and tetrazole derivatives, in addition to the derivatives of the oxazepin-4,7- dione using Schiff base and hydrazones compounds as intermediates . The first path: included the preparation of a number of Schiff base compounds (A1-6) by reacting aromatic benzaldehyde or ketone derivatives with amines and then cyclizing these compounds by α-chloroacetyl chloride to form derivatives of the tetracyclic azetidine-2-one (A7-12), as In this pathway, the derivatives of the thiazolidine-4-one (five membered ring) (A13-18) were prepared from the reaction of Schiff's bases with thioglycolic acid, as well as the cyclization of Schiff's bases compounds by sodium azide to prepare tetrazol derivatives (A19-22), creating the seven membered-ring oxazepine, 4- dione (A25-36) from the reactance of Schiff bases with maleic anhydride and phthalic anhydride respectively. The second path: This path included the preparation of a number of hydrazones (A45-49) from the reaction of substituted benzaldehyde with decanoic acid hydrazide (A44) through their reactance with different cyclic reagents, where they were reacted with α-chloroacetyl chloride to prepare substituted azitidine-2- one (A50-54) and its reaction with glycolic acid to synthesize the derivatives of thiazolidine-4-(A55-59), and through the reaction of hydrazones with sodium azide, we get derivatives for trazole (A60-64), and the derivatives of oxazepine-4,7-dione were created. (A65-74) from reacting the hydrazones (A44) with maleic anhydride afforded and phthalic anhydride again. The third path: In this path, the pyrazole-3-on derivative (A75) was prepared from the reaction of decanoic acid hydrazide (A44) with ethyl acetoacetate, and then the pyrazole-3-on derivative was reacted with benzaldehyde derivatives to obtain chalcon (A76-80). The fourth pathway: In this pathway, a derivative 1,2-bis(4- methoxybenzylidene)hydrazine (A81) was prepared from the reaction of tow equivalent moles of 4-methoxybenzaldehyde with aqueous hydrazine, after B which it was reacted with Schiff bases compounds (A1-6) to form of 1,2,4- triazine derivatives with via Diels-Alder like reaction (A82-86). The identity of the prepared compounds was determined using physical constants and spectroscopic methods (infrared and nuclear magnetic resonance spectroscopy) and the biological activity was evaluated in veterinary laboratories using two types of gram-positive and gram-negative bacteria. --- page 155 [OCR+] --- Synthesis and characterization heterocyclic compounds via cycloaddition reaction of imines and evaluation of their biological activity A Thesis Submitted By Ahmed Mahdi Salih To The council of the college of Education for Pure Science University of Mosul In Partial Fulfillment of the Requirements for the Degree of M. Sc. In Chemistry Supervised By Assist. Prof. Dr. Mohanad Yaqdhan Salih 2022 A.D. 1443 A.H. [OCR of page] Synthesis and characterization heterocyclic compounds via cycloaddition reaction of imines and evaluation of their biological activity A Thesis Submitted By Ahmed Mahdi Salih To The council of the college of Education for Pure Science University of Mosul In Partial Fulfillment of the Requirements for the Degree of M. Sc. In Chemistry Supervised By Assist. Prof. Dr. Mohanad Yaqdhan Salih 2022 A.D. 1443 A.H. --- page 156 [OCR+] --- University of Mosul College of Education For Pure Science Synthesis and characterization heterocyclic compounds via cycloaddition reaction of imines and evaluation of their biological activity Ahmed Mahdi Salih M. Sc. Thesis Chemistry Supervised By Assist. Prof. Dr. Mohanad Yaqdhan Salih 2022 A.D. 1443 A.H. [OCR of page] University of Mosul College of Education es fam For Pure Science seme Synthesis and characterization heterocyclic compounds via cycloaddition reaction of imines and evaluation of their biological activity Ahmed Mahdi Salih M. Sc. Thesis Chemistry Supervised By Assist. Prof. Dr. Mohanad Yaqdhan Salih 2022 A.D. 1443 AH.

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