تحضير وتشخيص وتقييم الفعالية الحيوية لعدد من العناصر الفلزية ثنائية التكافؤ مع ليكاندات قواعد شيف المشتقة من الهيدرازونات

الباحث

ظفر عماد توفيق أيوب

المشرف

ماهر عبد الرزاق محمد

الجامعة

جامعة الموصل

الكلية / القسم

كلية التربية للبنات / الكيمياء

الشهادة

ماجستير

السنة

2023

لغة الرسالة

عربي

الكلمات المفتاحية

قواعد شيف ; الهيدرازونات ; المعقدات الفلزية ; الفعالية الحيوية

This thesis includes the preparation and characterization of a number of complexes of cobalt (Co(II), nickel (Ni(II)), copper (Cu (II), zinc (Zn (II)), and cadmium (Cd (II)) ), and mercury Hg (II), with Schiff base ligands for the prepared hydrazones, which are (L1, L2, L3, L4, L5): L1 = (E)-N'-((2-hydroxynaphthalen-1-yl)methylene)benzohydrazide L2=(E)-2-hydroxy-N'-((2-hydroxynaphthalen-1yl)methylene) benzo hydrazide L3 = 2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide L4= N'-(1-(2-hydroxyphenyl)ethylidene)isonicotinohydrazide L5= N'-((2-hydroxynaphthalen-1-yl)methylene)-4-nitrobenzohydrazide The complexes were prepared from the direct interaction between metal (II) chloride with Schiff bases prepared in a neutral environment. The prepared ligands and complexes were identified using several techniques, including physical (melting point and molar conductivity) and spectroscopic measurements (atomic absorption spectrum, spectrophotometer UV-Vis, FT-IR, and Nuclear Resonance Spectrum Magnetic 13C-NMR, 1H-NMR of ligands (L1,L2,L3,L4) and their complexes (12,18,23) and gas Chromatography-mass spectrometry GC- Mass for ligandins (L1, L4) and their complexes (3, 8, 15, 22), as well as magnetic measurements, the studies showed The five ligands (L1- L5) give neutral electrolytic complexes at a ratio of 1:1 and 2:1 with the following formulas, respectively: [M(Ln)Cl]Cl [M(Ln)2]Cl2 Ln = L1, L2, L3, L4, L5 M = Co(II) , Ni(II) , Cu (II) , Zn (II) , Cd (II) , Hg (II) It was found from the study of the infrared spectrum, as well as from other studies, that ligands L1- L5 behave like three-pin ligands, each of which is linked through a nitrogen atom of the azomethine group, two phenolic oxygen atoms, and a carbonyl group. The values of the electronic spectra and magnetic sensitivity measurements showed that the cobalt (II) complexes are tetrahedral symmetric, except for the complex (1), which is octahedral [Co(L1)2]Cl2, while the nickel complexes are (II) Three stereo forms are [Ni(Ln)Cl]Cl, and the two complexes (2,26) are octahedral 2[Ni(Ln)2]Cl, complex (20) is tetrahedral [Ni(L4)Cl]Cl, and complex (8,14) takes the form of a square plane [Ni(L1) (Cl]Cl, while the complexes of copper (II) are all tetrahedral [Cu(L1-5)Cl]Cl, and the complexes of zinc (II) and cadmium ( II) and mercury (II) are all tetrahedral [M(L1-5)Cl]Cl also. M=Zn ,Cd , Hg A study evaluating the biological activity of ligands and a number of their complexes against two types of pathogenic bacteria (positive and gram- negative) Stauphylcoccusaureus and Escherichiacoli showed that the complexes have high effectiveness compared to the ligands derived from them, which are almost non-effective.

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