دراسة المعاملات الثرموداينميكية لدوائي الإيبوبروفين والميفانميك مع بعض المواد الفعالة سطحياً عند تركيز المذيل الحرج

الباحث

عائشة عبد الستار محمد خضر

المشرف

نهى محمد يحيى

الجامعة

جامعة الموصل

الكلية / القسم

كلية التربية للبنات / الكيمياء

الشهادة

ماجستير

السنة

2022

لغة الرسالة

عربي

الكلمات المفتاحية

الإيبوبروفين ; المواد الفعالة سطحياً ; تركيز المذيل الحرج ; الثرموداينميك

Non-Steroidal Anti-inflammatory Drugs (NSAIDs) such as ibuprofen and mefenamic acid of (10-1, 10-2, 10-3, 2x10-3M) carrying the surfactants aqueous solution of such as Tween 60 (polyoxyethylene (20) sorbitan monostearate) and Tween 80 (polyoxyethylene (20) sorbitan mononuclear) as well as with Triton X-100 (Octylphenolpoly (ethyleneglycolether) n=9) in the effect of temperatures (293, 303, 313,323) K on the surface tension were studied. The critical micelle concentration (CMC) were evaluated from the plot of surface tension versus concentrations of aqueous solution (mefenamic acid + surfactant) or (Ibuprofen + surfactant) thermodynamic constants were calculate at CMC such as heat of reaction (enthalpy) (ΔHm), Gibbis free energy of adsorption (ΔGads) and Gibbis free energy for the formation of micelles (ΔGm) as well as entropy (ΔSm), the results of (ΔHm) showed positive values refer to endothermic reaction , (ΔSm) also was showed positive, (ΔGm) asw showed negative refer to spontanous process of micelle formation This explains the solubility of drugs in aqueous solutions Where the values of (ΔGm) for ibuprofen range from -1.7 to -9.8 (KJ/mol), and for mefanamic acid range from -2.68 to -10.16 (KJ/mol), while the values of (ΔGads) for ibuprofen range from - 11.9 to -22.7 (KJ/mol), and for mefenamic acid, it ranges from -8.12 to -21.77 (KJ/mol), while the values of (ΔSm) for ibuprofen range from 11.67 to (J.mol-1.K-1) 98.71 And for mefenamic acid, it ranges from 14.25 to 96.45 (J.mol-1.K-1), which are positive values, and the increase in entropy indicates an increase in randomness in the solution as a result of the formation of micelles, which increases with increasing temperature, and the values of (ΔHm) are positive. For aqueous solutions of surface active substances with and without the drug, for ibuprofen it ranges from 2.998 to 27.67 (KJ/mol), and for mefanamic acid, it ranges from 3.7 to 20.99 (KJ/mol) and these values increase with increasing temperature. The results indicated that CMC increased with increasing temperature for Tween 60, Tween 80 and Triton X-100, as well as for the mixture of (Ibuprofen or mefenamic acid) with all the surfactants. The values of the surface concentration of the surfactant (Γmax), the area occupied by the surfactant molecule on the surface of the solution with air (Amin), and the surface pressure (Πcmc) were calculated. The values of the surface concentration of the surfactant (Γmax) were calculated, as for ibuprofen it ranged from 32.7 x 10-4 to 42.7 x 10-4 (mmol/m2), while for mefanmic acid it ranged from 35.13 x 10-4 to 42.83 x 10-4 (mmol/m2) , the area occupied by the surface active substance molecule on the surface of the solution with air (Amin), and the surface pressure (Πcmc) were calculated, as the values of (Amin) for mefanmic acid ranged from 4.33 x 10-22 (A2/molecule) to 5.12 x10-22 (A2/molecule) and for ibuprofen, it ranges from 5.01 x 10-22 (A2/molecule) to 5.6 x 10- 22 (A2/molecule). The effect of physiological pH was studied at the values of (pH 1, pH 5.8, pH 6.4, pH 7.4) and by drawing the relationship between surface tension and concentration, CMC values were obtained at each temperature, it was found that the best acidity function is (pH 5.8) compared to Other acid functions (pH 1, pH 6.4, pH 7.4) , and it was observed that there is a slight, unnoticeable effect of all the pH parameters on the CMC values and thermodynamic variables.

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